Over the past four decades, I have been developing a distinctive view of free will according to which it requires that agents be ultimately responsible for the creation or formation of their own wills (characters and purposes). Such a view of free will is, I believe, an important part of what it means to be a self or person and to live a human life. My goal in this paper, as in past writings, is to explain how a free will of this traditional kind—which I argue is incompatible with determinism—can be reconciled with modern developments in the sciences and philosophy. A free will of the ultimate kind I defend (often called “incompatibilist” or “libertarian”) has been under attack in the modern era since the seventeenth century by philosophers and scientists alike as obscure and unintelligible and has been dismissed by many twentieth century thinkers for its supposed lack of fit with modern images of humans in the natural and human sciences. Against these charges, I argue that an incompatibilist or non-determinist conception of free will can be defended without the usual appeals to obscure or mysterious forms of agency (Cartesian egos, noumenal selves, non-event agent causes, etc.) and can be reconciled with recent developments in the sciences—physical, biological, neurological, cognitive and behavioral. Indeed, I suggest that some modern developments in the sciences can help to unlock certain puzzles traditionally associated with free will. In the paper, I address criticisms that a nondeterminist free will does not allow sufficient agent control, reduces to mere chance or luck or randomness, fails to account of moral responsibility, and the like; and I relate such a free will to the nature of the self or person and to ideas of value, rationality and autonomy.