This paper uses transhuman claims for the evolutionary development of human persons through technology towards a superior species, Technosapiens or posthuman as a starting point for discussion about the meaning of human wisdom. I will suggest that transhumanity illuminates what human wisdom is by showing in a graphic way what it is not, and also why it is necessary to develop a strong notion of human wisdom, not only to safeguard the future of the human, but also to adjudicate where science is tempted towards scientism, or theology to dogmatism. While the basis for the claims of transhumanity rests on Enlightenment dreams of progress and humanist claims for the improvement of the human condition, the stress on the possibility of immortality through technology opens up a claim for a secularised account of eschatology and ‘ensoulment’ through computer technology. Transhumanist Nick Bostrom rejects the future as envisaged in biological evolutionary terms, while using the rhetoric of the ‘wisdom of nature’ in order to win public support. This paper will seek to develop an evolutionary account of human wisdom that weaves in a theological appreciation of the meaning of wisdom as virtue, drawing particularly on the thought of Thomas Aquinas. An exploration of the meaning of wisdom in Hebrew and New Testament thought shows clearly how transhuman goals for the future evolution of human to the posthuman express the opposite of wisdom, and in some sense acts as a counterfoil to wisdom in contemporary culture. In this case the theological wisdom that is sought is that which enables and fosters human relationships with God and other creatures. It is also conscious of social and political implications and ethical responsibility towards others. Transhumanity, on the other hand, seems to adhere to an individualism that uses technology in order to escape from the natural world, and present a portrait of the human that is severely diminished as a result. On the other hand, the practical wisdom that Aquinas develops gives insights into how best to respond theologically to the practical demands for technological progress through the manipulation of human becoming. Finally, I will argue that the ability for humans to grow in wisdom is best considered theologically through a Christological model, where humanity seeks to become imago Christi through the grace of the Holy Spirit acting in human lives and in the life of the human community.